Diabetes mellitus is characterized by too much glucose buildup in the blood. In _________diabetes, this is because the target cells of the body become resistant to the effects of__________ insulin ; in later stages of this type of diabetes, the pancreas begins to fail as well. In type 2 diabetes, this is because there are a decreased number of_________ cells available to secrete insulin; this results in an insufficient amount of insulin to meet the demands of the body.