Colchicine will affect anterograde transport because it will disintegrate the microtubules that will be the anterograde transport pathway. Then the material transport will not happen.
The vesicles that are at the axon terminal will move through the microtubules thanks to kinesin, a protein responsible for transporting materials dependent on ATP. When moving it will pass from the soma to the terminal and this will be the anterograde transport. When colchicine enters the system, the microtubule system will disintegrate, which will remove the transport pathway of the vesicles if it is applied to the axon, this will restrict the anterograde transport pathway.
So when this happens, what will happen is that the material generated by the neuron will accumulate in the soma and the material will not be transported. Even colchicine becomes toxic and kills the cell.
Therefore, we can confirm that colchicine will affect anterograde transport because it will disintegrate the microtubules that will be the anterograde transport pathway. Then the material transport will not happen.
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