A method of repairing DNA is called nucleotide excision repair. Chemicals (such as intercalating agents), radiation, and other mutagens continuously cause DNA damage.
Nucleotide excision repair (NER), base excision repair (BER), and DNA mismatch repair are the three excision repair processes that can fix single stranded DNA damage (MMR). The BER pathway can identify particular non-bulky lesions in DNA, but it can only repair damaged bases that have had specific glycosylases remove them. Similar to this, the MMR pathway only targets Watson-Crick base pairs that are mismatched.
The removal of DNA damage brought on by ultraviolet radiation is accomplished by the crucial excision mechanism known as nucleotide excision repair (NER) (UV). Bulky DNA adducts are produced as a result of UV DNA damage; the majority of these adducts are thymine dimers and 6,4-photoproducts. Once the damage is recognized, the brief section of single-stranded DNA that contains the lesion is removed. The single-stranded DNA that is still intact is used as a template by DNA polymerase to create a brief complimentary sequence.
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