The most common immunoglobulin isotype found on mucosal surfaces is secretory immunoglobulin A (IgA).
Two IgA molecules (dimeric IgA), a joining protein (J chain), and a secretory component make up secretory IgA. (SC).
Your immune system produces an antibody called immunoglobulin A (IgA). Mucous membranes, particularly those in the digestive and respiratory systems, contain IgA. Saliva, tears, and breast milk all contain it. A hereditary health condition called IgA deficiency can be handed down through generations.
IgA has long been considered a non-inflammatory antibody at mucosal locations. sIgA is concentrated in the mucus out layer [46] because of its polymeric structure and the oligosaccharide side chains of SC, which noncovalently cross-link microorganisms and encourage them to clump together in situ.
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